Carbontetrachloride Hepatotoxicity In Hypo And Hyperthyroidic Rats

Zusatztext

Carbontetrachloride is a model hepatotoxin. Toxicologists use it to study mechanisms of hepatocellular injury, whereas pharmacologists use it to study the efficacy of hepato-protective agents.Present results show that hypothyroidism itself causes mild centrilobular necrosis in the liver but hypothyroidic rats when treated with carbon tetrachloride showed no serious pathological lesions. While hyperthyroidic rats showed conditions resembling hepatitis and hyperthyroidic rats when treated with carbon tetrachloride showed no protective effect of thyroxine on carbon tetrachloride induced hepatic lesions. These results suggest that CCl4 toxicity is diminuted under hypothyroidic conditions. Histopathology of thyroid under present experimental conditions was also studied. Follicular collapse was observed in the thyroid gland of rats that were treated with carbontetrachloride. Significant loss of colloid was recorded in the thyroid of hypothyroidic rats. Several lesions in the thyroid gland were recorded in rats treated with PTU and carbontetrachloride.

Autorenportrait

Dr. Kalpana Chaudhary, M.Sc, M.Phil, PhD is an experienced researcher and an ardent teacher.She has completed her research in the field of Toxicology. She has research and teaching experience of 28 years. She has attended about 60 National and international seminars and presented more than 50 research papers. she has various awards to her credit.

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