Adiponectin : Implications in Health and Diseases

Zusatztext

Adiponectin is the name originated from its distinctive molecular characteristics (adipo + nectin = adiponectin) as it is a product of novel gene apM1 which is specific to adipocytes and uniquely possess a collagen-like domain with a nectin-like adherent property. Adiponectin is the most abundant peptide secreted by adipocytes, whose altered levels play a central role in obesity-related diseases, including insulin resistance/type 2 diabetes and cardiovascular disease. It is known to exert anti-diabetic and anti-atherosclerotic effects via adiponectin receptors (Adipors); AdipoR1 and AdipoR2. Adiponectin has direct actions in liver, skeletal muscle and the vasculature. Adiponectin administration in humans and rodents has insulin-sensitizing, anti-atherogenic, and anti-inammatory effects and in certain settings, also decreases body weight. Therefore, adiponectin replacement therapy in humans may suggest potential versatile therapeutic targets in the treatment of obesity, insulin resistance/type 2 diabetes, cardiovascular disease and atherosclerosis.

Autorenportrait

Dr. Seema Gupta (M.D. Biochemistry) GMC, Haldwani. Dr. V.N. Satyawali (M.D. Medicine), GMC, Haldwani. Dr. Sanjeev Kumar Shukla (Ph.D. Biotechnology), Research Scientist-II, Multidisciplinary Research Unit (MRU), Government Medical College, Haldwani, Nainital, Uttarakhand, India.

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