Recent Approaches for Enhancing the Solubility of Drugs

Zusatztext

Solubility is the phenomenon of dissolution of solid in liquid phase to give a homogenous system. Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown. It is generally recognized that poor solubility is one of the most frequently encountered difficulties in the field of pharmaceutics. Low solubility and subsequent unsatisfactory dissolution rate are often compromise with the oral bioavailability of drugs. This article demonstrates the various techniques which are used to enhance the aqueous solubility which can thus be a valuable aid to increase the efficiency and reducing side effect for the drugs. Hence, various techniques are used for the improvement of the solubility of poor water soluble drugs which include Hydrotropy, pH adjustment, Cosolvency, Misceller solubilization, Supercritical fluid techniques, Solid dispersion, Complexation, Microemulsion, use of surfectants and Nanonization.

Autorenportrait

Mr. Dushyant Kumar Dewangan has obtained his Bachelor degree in pharmacy from Columbia Institute of Pharmacy (CIP) Raipur, Chhattisgarh, INDIA in 2017. He is a recipient of the student of the year award from the college and has also attended many national seminars on the different aspects of pharmaceutical sciences.

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