Mechanisms in B-Cell Neoplasia

Zusatztext

The fourth workshop on Mechanisms in B-Ce11 Neoplasia was held in Bethesda. Maryland. at the National Institutes of Health on March 24. 25 and 26. 1986. The meeting was attended by approximately 150 participants and 58 presentations were given. The purpose of these workshops and the yearly publications has been to provide a means for exchanging the rapidly developing information in this field and to bring maJor problems into focus. Edited trans­ cripts of the 1983 and 1985 workshops were published by Editiones Roche Bas1e, Switzerland. Papers brought to the 1984 workshop were published in Current Topics in Microbiology and Immunology, Vol. 113. Numerous retrovira1 recombinant viral constructs are now in general use in a variety of test systems, both in vivo and in vitro. These are proving to have interesting bio10gica1-prQperties. ------- Kecent1y developed systems for inducing B cell tumors are described: 1) The development of spontaneous ~-ce11 tumors in transgenic mice carrying deregulated ml£ genes and the Ig heavy chain promoter; 2) a method for inducing ·p1asmacytomas in BAL~/c mice with short latent periods of ca 70 days by infecting pristane treated mice with retroviruses carrying various types of deregulated ml£ genes; 3) induction of pre-B cell tumors with erbB containing recombinant retroviruses; 4) induction of B-ce11 and other tumors by infection of neonates with recombinant retroviruses. Several retrovira1 constructs containing ml£ sequences do not induce B-ce11 tumors in pristane conditioned mice -.

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InhaltsangabeB-cell Tumors in Transgenic Mice Carrying c-mycSequences.- c-Myc-Induced Lymphomagenesis in Transgenic Mice and the Role of the Pvt-1 Locus in Lymphoid Neoplasia.- Lymphohematopoietic and Other Malignant Neoplasms Occurring Spontaneously in Transgenic Mice Carrying and Expressing MTV/myc Fusion Genes.- Induction of B-cell Tumors with Retroviral Constructs Containing Oncogenes.- Tumors of Newborn NFS/N Mice Infected with Murine Retroviruses Containing Avian v-Myc.- Induction of Clonal Monocyte/Macrophage Tumors invivo by a Mouse c-myc Retroviruses: Evidence for Secondary Transforming Events.- Induction of Hematopoietic Tumors Using a Viral Construct Containing c-myc cDNA from Normal Mouse Spleen.- Rapid Induction of Plasmacytomas in Mice by Pristane and a Murine Recombinant Retrovirus Containing an Avian v-myc and a Defective raf Oncogene.- Transformation and Insertional Mutagenesis in Vitro of Primary Hematopoietic Stem Cell Cultures.- Induction of B-cell and Other Tumors in Vitro.- Mammalian Cell Transformation by a Recombinant Murine Retrovirus Containing the Avian Erythroblastosis Virus erbB Gene.- Determinants of Abelson Murine Leukemia Virus Pathogenesis.- An In Vitro Model for Tumor Progression in Murine Lymphoid Cells.- Structural Modification of c-abl in Lymphoma and Leukemia.- Transposable Elements and Cancer.- B-Lymphocyte/Plasma Cell Growth Factors, Receptors.- Alpha-type B Cell Growth Factor and Complement Component C3: Their Possible Structural Relationship.- A Growth-Factor Dependent B-Cell Hybridoma.- A Growth Factor Required by Plasmacytoma Cells In Vitro.- Genes Affecting the Production or Action of B Cell-Active Lymphokines.- Lymphokine Regulation of Murine IgE Production.- Interleukin-4 (B Cell Growth Factor-II/Eosinophil Differentiation Factor) is a Mitogen and Differentiation Factor for Preactivated Murine B Lymphocytes.- Role of the LFA-1 Molecule in B Cell Differentiation.- Studies on Transferrin Receptor Expression in Mouse Plasmacytoma Cells.- Structure and Expression of c-myb Protooncogene mRNA in Murine B-Cells.- Chromosome Translocations, Breaks.- Genomic Activity and Translocation in Lymphocytes.- Possible Role of Immunoglobulin Recombination Sequences in the Genesis of Variant t (2;8) Translocations of Burkitt Lymphoma.- C-Myc Activation in Spontaneous Rat Immunocytomas Containing a 6;7 Chromosomal Translocation.- The Molecular Genetics of Human T Cell Leukemias and Lymphomas.- Molecular Genetics of Human B-cell Neoplasia.- C-myc and Functionally Related Oncogenes Induce Both High Rates of Sister Chromatid Exchange and Abnormal Karyotypes in Rat Fibroblasts.- Chromosomal Radiosensitivity During G2 Phase and Susceptibility to Plasmacytoma Induction in Mice.- Biology of B Cell Tumor Development.- Normal and Neoplastic B Cell Development in the Bursa of Fabricius.- Restrictions That Influence Avian Leukosis Virus-Induced Lymphoid Leukosis.- Benign Monoclonal Gammapathy (BMG).- DNA Rearrangement and Expression of the c-myc Gene in a Human Myeloma.- Inbred Strain Differences Influence the Focal Proliferation of Plasma Cells in Pristane Induced Oil Granuloma.- Molecular Analysis of myc Gene Mutants.- EBV-Virus, Burkitt's Lymphoma.- Induction of fgr Proto-oncogene mRNA in B Lymphocytes as a Consequence of Epstein- Barr Virus Infection.- Epstein-Barr Virus Induced Differentiation of Early B-Lineage Cells.- Epstein-Barr Virus Gene Expression During Primary B-Lymphocyte Infection, in Transformed and Burkitt Lymphoma-Derived Cell Lines.- Structure and Expression of Translocated c-myc Oncogenes: Specific Differences in Endemic, Sporadic and AIDS-Associated Forms of Burkitt Lymphomas.- EBV-Activation of Human B-Lymphocytes.- Regulation of c-myc Expression.- Myc Expression in vivo During Human Embryogenesis.- Expression of c-myc and c-fos During Phorbol Ester Induced Differentiation of B-type Chronic Lymphocytic Leukemia Cells.- Regulation of c-myc mRNA and Protein Levels During Activation of Normal Human B Ce

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