Cytokines in Hemopoiesis, Oncology, and AIDS
Mathias Freund/Hartmut Link/Karl Welte
InhaltsangabeOverview.- Colony Stimulating Factors:Past and Future.- Regulation of Hematopoietic Progenitor Cell Growth by Stimulating and Suppressing Cytokines.- Cytokine Interactions in Normal and Malignant Hematopoiesis.- Preclinical and In Vitro Data.- Colony Stimulating Factors in Normal Hematopoiesis.- Screening the Sensitivity of Hematopoietic Progenitor Cells to Different Growth Factors. Potential Importance in Therapy Trials with Colony Stimulating Factors.- Effect of Human Recombinant Interleukin-3 in Long-term Bone Marrow Culture.- Secretion of Colony-Stimulating Factor for Macrophages (M-CSF) and Granulocyte/Macrophages (GM-CSF) is Developmentally Regulated in Human Macrophages.- Expression of the M-CSF/CSF-1 Gene in Normal Human Alveolar Macrophages.- Surface Expression of Interleukin-2 Receptors and CD4 Molecules by Human Eosinophils is Induced by GM-CSF and IL-3.- Expression of Interleukin Receptors on Human Eosinophils, Basophils, and Mast Cells.- Chemiluminescene of Polymorphonuclear Leukocytes in Response to Interferons.- Glycolysis and Amino Acid Incorporation in IL-3-Dependent Cell Lines.- Fibroblast Colony Stimulating Activity of GM-CSF and IL-3 in Human Bone Marrow Cell Cultures.- Chromatin and DNA Methylation Changes of the Human Myeloperoxidase Gene During Myeloid Differentiation.- Retroviral-Mediated Transfer of Genes Encoding for Growth Factors into Human Hematopoietic Stem Cells.- Colony Stimulating Factors in Malignant Hematopoiesis.- Recruitment Therapy in Acute Myeloblasts Leukemia:A Different Approach to Improved Leukemia Treatment.- Effects of Hematopoietic Growth Factors on Myelodysplastic Syndrome Progenitors.- Combined Cytogenetic and Proliferation Studies of GM-CSF- Stimulated Bone Marrow Cells in Myelodysplasia and Acute Leukemia.- Recombinant Haemopoietic Factors (IL-3, IL-4, GM-CSF) Fail to Induce the Expression of Leucocyte Adhesion Receptors on Leukaemia Myeloid Colonies.- In Vitro Evaluation of Antiproliferative Activity of CCRF-CEM Supernatant on Lymphoid and Nonlymphoid Leukemic Cells.- TNF-?, IL-6, and Phorbol Ester but Not G-, M-, GM-CSF, IL-3, and IL-4 Induce Monocytic Differentiation and Modulate Expression of C-FOS, C-FMS, and C-MYC in the Human Monoblast Line THP-1.- In Vitro and In Vivo Inhibitory Effects of Interferon ? 2b on CML Granuloerythroid Precursors.- Several Cytokines Do Not Influence Activity of P210BCR-ABL Kinase in K562 Cells.- Colony Stimulating Factors in Nonhematopoietic Cells.- Target Cell Specifity of Hematopoietic Growth Factors.- Growth Factor-Dependent Stimulation of Primary Human Tumor Cells.- Stimulation of Colony Formation of Various Human Carcinoma Cell Lines by rhGM-CSF and rhIL-3.- Effects of Recombinant Cytokines on Clonogenic Cells from Primary Human Tumors.- Tumor Necrosis Factor and Interferon.- Mechanisms of TNF Action:Analysis of Receptor Structure and of Regulatory Circuits Controlling Receptor Expression and TNF-Production.- Synergism of Lymphotoxin and Interferon-? in the Growth Inhibition of Breast Cancer Cell Line MCF-7.- In Vitro Effect of Human Interferon-Gamma on Sister Chromatid Exchange Frequency and Proliferation of Cultured Human Amniotic Fluid Cells.- Tumor Necrosis Factor/Cachectin Production by B-Cell Chronic Lymphocytic Leukemia and Hairy Cell Leukemia Cells.- Interleukin-2.- Activation of Cytolytic Effector Cells.- Regulatory Effect of Recombinant Cytokines on NK Cell Differentiation from Early Marrow Precursors.- Human NK Clones Regulate B-cell Development by Release of IFN-? and TNF-?.- Expression of High Affinity IL-2 Receptors on a Hodgkin Cell Line.- Autologous Antileukemia Cytotoxicity Induced by PBL and BM Culture with rIL-2; Use in Autologous BMT for Inducing GVL?.- Interleukin-2-Induced Lymphokine-Activated Killer (LAK) Cells Against Human Leukemia:Improvement of Cytotoxicity by Combinations of Lymphokines or Cytokines.- Interleukin-2 (IL-2) in Acute Leukemia:In Vitro Studies and Possible Clinical Applications.- Other Effects and F
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The clinical and experimental effects of cytokines have been realized for a long time. The clinical effects of tumor necrosis factor were noted almost 100 years ago. The basic biological effects of interferons and the hemopoietic growth factors have been known for more than 20 years. Given the basis of modern molecular biotechniques, information concern ing the mediators of cellular interactions is expanding almost exponentially. New principles in the regulation of cell growth, microenvironment, immune response, and malignancy are being discoverd right now. New therapeutic options are becoming available and have, in some areas, already crossed the threshold of clinical application. However, the way forward might be more complicated than we are in a position to recognize today. Some of the first optimistic expectations have not yet been fulfilled. Nevertheless, we are experiencing a revolution in medicine. To contribute to this process and to stimulate scientific communi in this field, we have initiated the international symposia on cytokines cation in hemopoiesis, oncology and aids. Major contributions from the first sym posium are published in this book. We thank all the authors for their contri butions, particularly those from the Hannover Medical School, who have worked hard to realize the congress and prepare these proceedings. We also thank the pharmaceutical companies whose support made this book possible. Finally we thank Professors Deicher, Poliwoda, and Riehm, heads of the Departments of Hematology and Oncology, Immunology, and Pediatric Hematology and Oncology, respectively, who encouraged us and gave us their firm support.
Weitere Details
Erschienen: 30.11.1990
Umfang: lvii, 762 S., 71 s/w Illustr., 762 p. 71 illus.
Sprache: ENG
Einband: KT
ISBN/EAN: 9783540522812
Umbreit-Nr.: 4369260
