Human Genetic Variation in Response to Medical and Environmental Agents: Pharmacogenetics and Ecogenetics

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InhaltsangabePharmacogenetics and Ecogenetics: The Problem and Its Scope.- I. Multifactorial Pharmacogenetics in Man.- Multifactorial Inheritance and Heritability in Pharmacogenetics.- Human Pharmacokinetics.- Twin Studies in Pharmacogenetics.- Search for Single Gene Effects in Multifactorial Inheritance in Pharmacogenetics.- II. Monogenic Pharmacogenetics in Man.- G6PD Variants.- Pseudocholinesterase Variation.- Aromatic Amines and Hydrazines, Drug Acetylation, and Lupus Erythematodes.- Polymorphism of Human Serum Paraoxonase.- Malignant Hyperthermia.- Drug Sensitivity in Hereditary Hepatic Porphyria.- Assets and Limitations of Animal Models.- III. Human Psychopharmacogenetics.- Psychopharmacogenetics: An Overview and New Approaches.- Alcohol and Alcoholism.- Human Biochemical Genetics of Plasma Dopamine-?-Hydroxylase and Erythrocyte Catechol-O-Methyltransferase.- I. Human Genetics and Nutritional Problems.- Intestinal Lactase Polymorphisms and Dairy Foods.- Genetic and Nongenetic Hyperlipidemia and Western Diets.- Can Iron Fortification of Flour Cause Damage to Genetic Susceptibles (Idiopathic Haemochromatosis and ?-Thalassaemia Major)?.- II. Genetic Variation in Mutagenesis and Carcinogenesis.- Genetic Aspects of Induced Mutation.- The Ah Locus: Aromatic Hydrocarbon Responsiveness. of Mice and Men.- Aryl Hydrocarbon Hydroxylase in Man and Lung Cancer.- An Overview of Animal and Microbial Test Systems for Carcinogenesis and Mutagenesis: Problems With Human Variation.- III. General Problems in Ecogenetics.- Ecogenetics: A View From the U.S. President's Science Advisory Office.- Bioethical Problems in Pharmacogenetics and Ecogenetics.

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