Clinical Epidemiology

Zusatztext

Focusing on improving the diagnosis, prognosis, and management of human disease, this book takes on the issues of research design, measurement, and evaluation which are critical to clinical epidemiology. This second edition of Clinical Epidemiology: Practice and Methods opens with how best to frame a clinical research question, the ethics associated with doing a research project in humans, and the definition of various biases that occur in clinical research. From there, it continues by examining issues of design, measurement, and analysis associated with various research designs, including determination of risk in longitudinal studies, assessment of therapy in randomized controlled clinical trials, and evaluation of diagnostic tests, and then delves into the more specialized area of clinical genetic research, before concluding with basic methods used in evidence-based decision making including critical appraisal, aggregation of multiple studies using meta-analysis, health technology assessment, clinical practice guidelines, development of health policy, translational research, how to utilize administrative databases, and knowledge translation. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and practical advice to ensure real world success.Comprehensive and authoritative, Clinical Epidemiology: Practice and Methods, Second Edition is intended to educate researchers on how to undertake clinical research and should be helpful not only to medical practitioners but also to basic scientists who want to extend their work to humans, to allied health professionals interested in scientific evaluation, and to trainees in clinical epidemiology.

Autorenportrait

InhaltsangabePart I: Introduction 1. On Framing the Research Question and Choosing the Appropriate Research Design            Patrick S. Parfrey and Pietro Ravani 2. Research Ethics for Clinical Researchers            John D. Harnett and Richard Neuman 3. Definitions of Bias in Clinical Research            Geoffrey Warden Part II: Longitudinal Studies 4. Longitudinal Studies 1: Determination of Risk            Sean W. Murphy 5. Longitudinal Studies 2: Modeling Data Using Multivariate Analysis            Pietro Ravani, Brendan J. Barrett, and Patrick S. Parfrey 6. Longitudinal Studies 3: Data Modeling Using Standard Regression Models and Extensions            Pietro Ravani, Brendan J. Barrett, and Patrick S. Parfrey 7. Longitudinal Studies 4: Matching Strategies to Evaluate Risk            Matthew T. James 8. Longitudinal Studies 5: Development of Risk Prediction Models for Patients with Chronic Disease            Navdeep Tangri and Claudio Rigatto Part III: Randomized Controlled Clinical Trials 9. Randomized Controlled Trials 1: Design            Bryan M. Curtis, Brendan J. Barrett, and Patrick S. Parfrey 10. Randomized Controlled Trials 2: Analysis            Robert N. Foley 11. Randomized Controlled Trials 3: Measurement and Analysis of Patient-Reported Outcomes            Michelle M. Richardson, Megan E. Grobert, and Klemens B. Meyer 12. Randomized Controlled Trials 4: Biomarkers and Surrogate Outcomes            Claudio Rigatto and Brendan J. Barrett 13. Randomized Controlled Trials 5: Determining the Sample Size and Power for Clinical Trials and Cohort Studies            Tom Greene 14. Randomized Controlled Trials 6: On Contamination and Estimating the Actual Treatment Effect            Patrick S. Parfrey 15. Randomized Controlled Trials 7: Analysis and Interpretation of Quality of Life Scores            Robert N. Foley and Patrick S. Parfrey 16. Randomized Controlled Trials 8: Planning, Monitoring, and Execution            Elizabeth Hatfield, Elizabeth Dicks, and Patrick S. Parfrey Part IV: The Basics for Other Clinical Epidemiology Methods 17. Evaluation of Diagnostic Tests            John M. Fardy and Brendan J. Barrett 18. Qualitative Research in Clinical Epidemiology            Deborah M. Gregory and Christine Y. Way 19. Health Economics in Clinical Research            Braden J. Manns Part V: Clinical Genetic Research 20. Clinical Genetic Research 1: Bias            Susan Stuckless and Patrick S. Parfrey 21. Clinical Genetic Research 2:  Genetic Epidemiology of Complex Phenotypes            Darren D. O'Rielly and Proton Rahman 22. Clinical Genetic Research 3: Genetics ELSI (Ethical, Legal and Social Issues) Research            Daryl Pullman and Holly Etchegary Part VI: Methods in Evidence-Based Decision Making 23. Evidence-Based Decision Making 1: Critical Appraisal            Laurie K. Twells 24. Evidence-Based Decision Making 2: Systematic Reviews and Meta-Analysis            Aminu Bello, Natasha Wiebe, Amit Garg, and Marcello Tonelli 25. Evidence-Based Decision Making 3: Health Technology Assessment            Daria O'Reilly, Kaitryn Campbell, Meredith Vanstone, James M. Bowen, Lisa Schwartz, Nazila Assasi, and Ron Goeree 26. Evidence-Based Decision Making 4: Development and Limitations of Clinical Practice Guidelines            Bruce Culleton 27. Evidence-Based Decision-Making 5: Translational Research</p

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